Not really. We run a public DNS resolver (DoH and DoT only) on Fly and it turns out, some DNS clients / stubs (like Tailscale & AdGuard), send a query for ipv4only.arpa to determine if the endpoint serving the URL is indeed a DNS resolver.
Our code forwards incoming non-internal DNS queries to fdaa::3 due to the guarantee that it should just work (or at least, it shouldn’t really be breaking anything):